Search results for " Stimuli-responsive polymers"

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Development of stimulus-sensitive electrospun membranes based on novel biodegradable segmented polyurethane as triggered delivery system for doxorubi…

2022

In this work, redox-sensitive polyurethane urea (PUU) based electrospun membranes have been exploited to chemically tether a pH-sensitive doxorubicin derivative achieved by linking a lipoyl hydrazide to the drug via a hydrazone linkage. First, the lipoyl-hydrazone-doxorubicin derivative labelled as LA-Hy-Doxo has been syn- thesized and characterized. Then, the molecule has been tethered, via a thiol-disulfide exchange reaction, to the redox-sensitive PUU (PolyCEGS) electrospun membrane. The redox-sensitive PolyCEGS PUU has been produced by using PCL-PEG-PCL polyol and glutathione-tetramethyl ester (GSSG-OMe)4 as a chain extender. The LA-Hy- Doxo tethered electrospun membrane has showed a du…

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoDoxorubicinPolyurethanesPolyurethane Stimuli-responsive polymers Electrospun membrane Doxorubicin Lipoic acidCancer therapyHydrazonesHumansAntineoplastic AgentsMicellesBiomaterials Advances

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PEPhysical Sciences and Engineering
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